The Town of Neepawa is located along the Yellowhead Highway 16 and Highway 5, the Parks Route.

The community is located 45 minutes northeast of Brandon, the region's largest centre, and 2 hours northwest of Winnipeg, the provincial capital. Neepawa is also located 1 hour from Riding Mountain National Park.

The Town of Neepawa features a 3,500 foot runway that is able to service air ambulance and small jets.

The Canadian Pacific Railway services Neepawa for freight transportation.

Neepawa is serviced by both Grey Goose and Greyhound Bus lines. Numerous buses make stops in Neepawa each day.

Daily Courier services are provided by three major companies. Additionally, transfer services are provide by Gladstone Transfer and Gardewine, which maintains a depot in Neepawa.